Safety and Protective Efficacy of a Candidate Vector-Based Vaccine for Bovine Tuberculosis

This study presents the results of a survey safety and protective efficacy candidate vector-based vaccine for bovine tuberculosis, using an influenza vector with NS1 mutation expressing M. bovis antigens ESAT-6 TB10.4. We vaccinated Balb/c outbred mice two times at 21 days apart. Our experimental design includes immunised or without adjuvant 15% Montanide Gel. The vaccine’s was determined by biometric analysis, assessed bacteriological histological experiments following virulent bovis-8 strain challenge. data indicated that adjuvant-free version ensured complete protection from infection in mice.